Johannes Ring

This entirely revised edition of the successful work presents the state of the art in clinics, research and practical management of atopic dermatitis - eczema. The wide variability in clinical morphology including differences between age groups and ethnicities is illustrated by color pictures including the typical minimal manifestations or “stigmata” suggestive of atopy. The dramatic rise in the prevalence of this disease over the last few decades is reflected by detailed analyses of epidemiological data from all over the world. In-depth descriptions of key pathophysiological mechanisms including epidermal barrier, molecular genetics, itch pathophysiology and modern cellular immunology offer readers a deeper understanding of the complex events leading to the often excruciating symptoms. Treatment – and management – comprises all aspects from elicitor avoidance to basic emollient skin care, immuno-modulating treatments both topical and systemic, up to the latest advances in kinase inhibitors and biologics.In turn, the book discusses the role of the microbiome and antimicrobial treatments as well as phototherapy, provides dietary recommendations for individuals with food allergies, and explores psychosocial aspects of the disease. Environmental influences are considered with regard to irritants and allergens. All recommendations are based on current national and international guidelines. The complex management strategies for this disease have led to the emergence of educational programs (Eczema Schools), which the authors have developed and promoted at the national and international level. This new revised edition of Atopic Dermatitis - Eczema will be an invaluable asset for dermatologists, allergists, pediatricians and general practitioners, but also for all related health personnel and patient organizations interested in gaining a fuller understanding of this widespread skin disease.

This entirely revised edition of the successful work presents the state of the art in clinics, research and practical management of atopic dermatitis - eczema. The wide variability in clinical morphology including differences between age groups and ethnicities is illustrated by color pictures including the typical minimal manifestations or “stigmata” suggestive of atopy. The dramatic rise in the prevalence of this disease over the last few decades is reflected by detailed analyses of epidemiological data from all over the world. In-depth descriptions of key pathophysiological mechanisms including epidermal barrier, molecular genetics, itch pathophysiology and modern cellular immunology offer readers a deeper understanding of the complex events leading to the often excruciating symptoms. Treatment – and management – comprises all aspects from elicitor avoidance to basic emollient skin care, immuno-modulating treatments both topical and systemic, up to the latest advances in kinase inhibitors and biologics.In turn, the book discusses the role of the microbiome and antimicrobial treatments as well as phototherapy, provides dietary recommendations for individuals with food allergies, and explores psychosocial aspects of the disease. Environmental influences are considered with regard to irritants and allergens. All recommendations are based on current national and international guidelines. The complex management strategies for this disease have led to the emergence of educational programs (Eczema Schools), which the authors have developed and promoted at the national and international level. This new revised edition of Atopic Dermatitis - Eczema will be an invaluable asset for dermatologists, allergists, pediatricians and general practitioners, but also for all related health personnel and patient organizations interested in gaining a fuller understanding of this widespread skin disease.

This book presents the state of the art in research into atopic dermatitis, or atopic eczema, and provides numerous effective practical management recommendations that are grounded in the immense clinical experience of the author. A scientific evidence-based approach to the subject is adopted, progressing from clinical symptoms in different disease stages, molecular genetics, and pathophysiology through to treatment and prevention. All aspects of patient management are covered, including diagnostics, avoidance strategies, emollient therapy, and acute treatment of eczema and itch. Diverse special therapeutic approaches are discussed, ranging from glucocorticoids, topical calcineurin inhibitors, and antimicrobial therapy through to UV therapy, allergen-specific immunotherapy, systemic immunosuppressive therapy, and emerging options. Environmental influences are considered, and there is a focus on the whole human being, with attention to psychosocial aspects of the disease and the benefit of educational programs such as “eczema schools”. Atopic Dermatitis will be invaluable for dermatologists, allergists, pediatricians, and general practitioners and informative for other interested persons and sufferers.

This book presents the state of the art in research into atopic dermatitis, or atopic eczema, and provides numerous effective practical management recommendations that are grounded in the immense clinical experience of the author. A scientific evidence-based approach to the subject is adopted, progressing from clinical symptoms in different disease stages, molecular genetics, and pathophysiology through to treatment and prevention. All aspects of patient management are covered, including diagnostics, avoidance strategies, emollient therapy, and acute treatment of eczema and itch. Diverse special therapeutic approaches are discussed, ranging from glucocorticoids, topical calcineurin inhibitors, and antimicrobial therapy through to UV therapy, allergen-specific immunotherapy, systemic immunosuppressive therapy, and emerging options. Environmental influences are considered, and there is a focus on the whole human being, with attention to psychosocial aspects of the disease and the benefit of educational programs such as “eczema schools”. Atopic Dermatitis will be invaluable for dermatologists, allergists, pediatricians, and general practitioners and informative for other interested persons and sufferers.

Allergy is one of the major health problems of most modern societies. Although allergic diseases are well-known for almost two hundred years, their prevalence has increased dramatically over the last decades. Allergic reactions manifest in various organs, most commonly in the skin and mucous membranes, the frontier surfaces where the contact between the individual and the environment takes place. In a very concise and practical way this book covers all aspects of allergic reactions from pathophysiology to diagnosis, therapy and prevention with a strong focus on relevant aspects for the everyday work of the practising dermatologist and allergist in the hospital or office. This book reflects the rich personal experience of a German allergist with international training and reputation, who is active in immunology and allergy research and practice for almost 30 years. In this book, not only IgE-mediated allergic reactions are covered but all other kinds of allergies such as atopic eczema, contact dermatitis, drug eruptions, anaphylaxis and food allergies are equally represented as well as psychosomatic aspects and problems of environmental intolerances.

Die Zunahme pathophysiologischer Erkenntnisse im Bereich der Der- matologie hat auch zu einer wesentlichen Erweiterung therapeutischer Ansatze gefiihrt. Waren friiher therapeutische Bemiihungen besonders bei entziindlichen Dermatosen hauptsachlich durch Anwendung auBerlicher TherapiemaBnahmen gekennzeichnet, so verfUgt der Dermatologe heute iiber hochdifferente, systemische Therapeutika wie Antibiotika, Gluko- kortikoide, Immunsuppressiva, Retinoide oder Zytostatika u. a., mit denen es gelingt, viele Hauterkrankungen wesentlich zu bessern oder zur Abheilung zu bringen. Die groBe Vielfalt sehr wirksamer innerlicher und auBerlicher Thera- peutika mit entsprechenden Nebenwirkungen erfordert vonjedem Haut- arzt entsprechende pharmakologische Kenntnisse zur Durchfiihrung notwendiger Kontrolluntersuchungen verschiedenster allgemeiner kli- nisch-chemischer Parameter, urn die jeweilige Therapie zu iiberwachen und Nebenwirkungen friihzeitig zu erkennen. In dem vorliegenden Buch wird ein Uberblick iiber das Arsenal an Wirkstoffen geboten, die heutzutage in der dermatologischen Therapie eingesetzt werden konnen. 1m Rahmen der auBerlichen Behandlung wird auch der indifferenten Dermatotherapie mit Grundlagen (Salbe, Creme, Paste, Lotio) besondere Aufmerksamkeit geschenkt. Dies scheint be- sonders wichtig in einer Zeit, in der man meint, den Dermatologen durch Richtlinien die Behandlung mit sogenannten wirkstofffreien Externa beschneiden zu miissen. Selbstverstandlich findet sich auch eine ein- gehende Besprechung der Wirkstoffe, die zur Behandlung bei Hauter- krankungen ihren Einsatz finden. Mit eingeschlossen sind Antiallergika sowie auch Pharmakotherapie in der Phlebologie und Proktologie sowie Andrologie. Breiter Raurn -und das ist wichtig -wird auch der innerlichen und auBerlichen Anwendung von Glukokortikosteroiden einschlieBlich der moglichen Nebenwirkungen an der Haut gewahrt. Neuere und noch in der Diskussion befindliche Therapieverfahren werden erwahnt, aber vor allen Dingen bewahrte herausgestellt.