Kenneth M. Weiss

Even after 150 years, Darwin’s theory of evolution by natural selection is irresistibly compelling. But how can this idea—in which competition prevails—be consistent with all that we know about the thoroughly cooperative nature of life at the genetic and cellular level? This book reconciles these discrepancies.Assembling a set of general principles, authors Kenneth Weiss and Anne Buchanan build a comprehensive, unified theory that applies on the evolutionary time scale but also on the developmental and ecological scales where daily life is lived, and cells, organisms, and species interact. They present this story through a diversity of examples spanning the fundamental challenges that organisms have faced throughout the history of life. This shows that even very complex traits can be constructed simply, based on these principles. Although relentless competitive natural selection is widely assumed to be the primary mover of evolutionary change, The Mermaid’s Tale shows how life more generally works on the basis of cooperation. The book reveals that the focus on competition and cooperation is largely an artifact of the compression of time—a distortion that dissolves when the nature and origins of adapted life are viewed primarily from developmental and evolutionary time scales.

Darwinian theory, with genes at its center, still frames our discussion of evolution. Yet now the picture within the frame–a portrait rendered in detail at the cellular and molecular level–contains the real stuff of today’s big questions about living organisms. Genetics and molecular biology have revealed a new realm of complexity in life, with major implications for how we understand evolution. Genetics and the Logic of Evolution provides a much-needed overview and analysis of general principles and patterns of evolution in light of contemporary biology. Taking a functional approach to explain how genes are used across the diverse range of species, the authors consider: *Basic concepts and principles of biological complexity *Alternative and supplemental principles to Darwinian theory *Building blocks of life: how DNA, RNA, and genes work in single-cell and multi-cellular organisms *Communication within an organism *Detection and perception of the environment *Evolutionary order and disorder and the sometimes fluid relationships between phenotypes and genotypes Working outwards from the molecular level, Genetics and the Logic of Evolution moves its discourse towards a broader sense of life and how organisms live it. Written to be both scientifically rigorous and accessible to the layman, this treatment offers students and practitioners a refreshingly grand tour of the most important generalizations to emerge from recent biological research.

Recent developments in molecular and computational methods have made it possible to identify the genetic basis of any biological trait, and have led to spectacular advances in the study of human disease. This book provides an overview of the concepts and methods needed to understand the genetic basis of biological traits, including disease, in humans. Using examples of qualitative and quantitative phenotypes, Professor Weiss shows how genetic variation may be quantified, and how relationships between genotype and phenotype may be inferred. This book will appeal to many biologists and biological anthropologists interested in the genetic basis of biological traits, as well as to epidemiologists, biomedical scientists, human geneticists and molecular biologists.