Peter Coveney

The visionary science behind the digital human twins that will enhance our health and our futureVirtual You is a panoramic account of efforts by scientists around the world to build digital twins of human beings, from cells and tissues to organs and whole bodies. These virtual copies will usher in a new era of personalized medicine, one in which your digital twin can help predict your risk of disease, participate in virtual drug trials, shed light on the diet and lifestyle changes that are best for you, and help identify therapies to enhance your well-being and extend your lifespan—but thorny challenges remain.In this deeply illuminating book, Peter Coveney and Roger Highfield reveal what it will take to build a virtual, functional copy of a person in five steps. Along the way, they take you on a fantastic voyage through the complexity of the human body, describing the latest scientific and technological advances—from multiscale modeling to extraordinary new forms of computing—that will make “virtual you” a reality, while also considering the ethical questions inherent to realizing truly predictive medicine.With an incisive foreword by Nobel Prize–winning biologist Venki Ramakrishnan, Virtual You is science at its most astounding, showing how our virtual twins and even whole populations of virtual humans promise to transform our health and our lives in the coming decades.

The visionary science behind the digital human twins that will enhance our health and our futureVirtual You is a panoramic account of efforts by scientists around the world to build digital twins of human beings, from cells and tissues to organs and whole bodies. These virtual copies will usher in a new era of personalized medicine, one in which your digital twin can help predict your risk of disease, participate in virtual drug trials, shed light on the diet and lifestyle changes that are best for you, and help identify therapies to enhance your well-being and extend your lifespan—but thorny challenges remain.In this deeply illuminating book, Peter Coveney and Roger Highfield reveal what it will take to build a virtual, functional copy of a person in five steps. Along the way, they take you on a fantastic voyage through the complexity of the human body, describing the latest scientific and technological advances—from multiscale modeling to extraordinary new forms of computing—that will make “virtual you” a reality, while also considering the ethical questions inherent to realizing truly predictive medicine.With an incisive foreword by Nobel Prize–winning biologist Venki Ramakrishnan, Virtual You is science at its most astounding, showing how our virtual twins and even whole populations of virtual humans promise to transform our health and our lives in the coming decades.

By the end of the twenty-first century, computer-based modelling and simulation will be integral to the way clinical decisions are taken. Drugs will be selected on the basis of an individual patient's "digital profile", while clinical treatments will be tailor-made for the individual in question. For this to come to pass, however, we must prepare for a future where we can simulate our own bodies with precision, drawing upon remarkable advances in information technology, computer, mathematical, physical and engineering science, data management, and high performance computing. Computational Biomedicine lays the foundations for a new approach to the subject - one that unifies the different strands of a broad-ranging subject, and demonstrates how computational biomedicine is a powerful tool with the potential to revolutionise our understanding of the human body, and the therapeutic strategies available to maintain and protect it. Written by a team of world-leading experts in the field, it explores the modelling of physiological systems at different scales - cells, tissues, organs - before considering the issues around biomedical computing, and data collection and analysis. It emphasises how a theoretical understanding of computational biomedicine translates into practice, with illustrative examples and case studies used throughout. Computational Biomedicine is the perfect introduction to the subject for anyone new to the field, from student to researcher. Online Resource Centre The Online Resource Centre to accompany Computational Biomedicine features figures from the book in electronic format, for download by registered adopters.

"SCIENCE JOURNALISM AT ITS BEST. . . An impeccably researched, amazingly up-to-date, crisply written and well-illustrated survey."--NatureAt the cutting edge of the sciences, a dynamic new concept is emerging: complexity. In this groundbreaking new book, Peter Coveney and Roger Highfield explore how complexity in mathematics, physics, biology, chemistry, and even the social sciences is transforming not only the way we think about the universe, but also the very assumptions that underlie conventional science. Complexity is a watchword for a new way of thinking about the behavior of interacting units, whether they are atoms, ants in a colony, or neurons firing in a human brain. The rise of the electronic computer provided both the key and the catalyst to our exploration of complexity. A new generation of computers that runs on light and exploits the bizarre properties of quantum mechanics promises to deepen our understanding still further. The advances we have already witnessed are spectacular. The authors take us inside laboratories where scientists are evolving the genetic molecules that enabled life to emerge on earth and generating universes teeming with virtual creatures in cyber-space. We witness the utterly realistic behavior of a school of virtual fish--computer-generated replicas that have been trained to swim gracefully, hunt for food, and scatter at the approach of a leopard shark. Compelling in its clarity, far-reaching in its implications, vibrant with the excitement of new discovery, Frontiers of Complexity is an arresting account of how far science has come in the past fifty years and an essential guide to the rapidly approaching future." A] MARVELOUS AND COMPREHENSIVE WORK . . . Virtually any scientist or interested lay reader will find this book engrossing, edifying and inspiring."--Publishers Weekly (starred review)