Peter Müller

Already popular in the analysis of medical device trials, adaptive Bayesian designs are increasingly being used in drug development for a wide variety of diseases and conditions, from Alzheimer’s disease and multiple sclerosis to obesity, diabetes, hepatitis C, and HIV. Written by leading pioneers of Bayesian clinical trial designs, Bayesian Adaptive Methods for Clinical Trials explores the growing role of Bayesian thinking in the rapidly changing world of clinical trial analysis.The book first summarizes the current state of clinical trial design and analysis and introduces the main ideas and potential benefits of a Bayesian alternative. It then gives an overview of basic Bayesian methodological and computational tools needed for Bayesian clinical trials. With a focus on Bayesian designs that achieve good power and Type I error, the next chapters present Bayesian tools useful in early (Phase I) and middle (Phase II) clinical trials as well as two recent Bayesian adaptive Phase II studies: the BATTLE and ISPY-2 trials. In the following chapter on late (Phase III) studies, the authors emphasize modern adaptive methods and seamless Phase II–III trials for maximizing information usage and minimizing trial duration. They also describe a case study of a recently approved medical device to treat atrial fibrillation. The concluding chapter covers key special topics, such as the proper use of historical data, equivalence studies, and subgroup analysis.For readers involved in clinical trials research, this book significantly updates and expands their statistical toolkits. The authors provide many detailed examples drawing on real data sets. The R and WinBUGS codes used throughout are available on supporting websites.Scott Berry talks about the book on the CRC Press YouTube Channel.

Already popular in the analysis of medical device trials, adaptive Bayesian designs are increasingly being used in drug development for a wide variety of diseases and conditions, from Alzheimer’s disease and multiple sclerosis to obesity, diabetes, hepatitis C, and HIV. Written by leading pioneers of Bayesian clinical trial designs, Bayesian Adaptive Methods for Clinical Trials explores the growing role of Bayesian thinking in the rapidly changing world of clinical trial analysis.The book first summarizes the current state of clinical trial design and analysis and introduces the main ideas and potential benefits of a Bayesian alternative. It then gives an overview of basic Bayesian methodological and computational tools needed for Bayesian clinical trials. With a focus on Bayesian designs that achieve good power and Type I error, the next chapters present Bayesian tools useful in early (Phase I) and middle (Phase II) clinical trials as well as two recent Bayesian adaptive Phase II studies: the BATTLE and ISPY-2 trials. In the following chapter on late (Phase III) studies, the authors emphasize modern adaptive methods and seamless Phase II–III trials for maximizing information usage and minimizing trial duration. They also describe a case study of a recently approved medical device to treat atrial fibrillation. The concluding chapter covers key special topics, such as the proper use of historical data, equivalence studies, and subgroup analysis.For readers involved in clinical trials research, this book significantly updates and expands their statistical toolkits. The authors provide many detailed examples drawing on real data sets. The R and WinBUGS codes used throughout are available on supporting websites.Scott Berry talks about the book on the CRC Press YouTube Channel.

Learn how to be fully present in the ever-changing moment • Explains how to use the oracle for divination, detailing the 64 hexagrams and the esoteric significance of each changing line • Explores key concepts that are culturally embedded in the Chinese understanding of the I Ching to give readers greater confidence in interpreting the oracle’s answers • Teaches readers the way to secure favorable outcomes by properly aligning with each moment of change For millennia people have consulted the I Ching to make sense of life’s challenges. This new translation of the ancient classic teaches readers how to be fully present in the ever-changing moment. With the wisdom of twenty years of contemplation and study, Peter Muller guides readers through the mechanics of using the Oracle. From phrasing one’s questions with intention and integrity to understanding the innerworkings of each of the 64 hexagrams, the author reveals his mastery over the secrets of the I Ching. He explores the esoteric significance of each changing line and gives illustrations from daily life to amplify their meanings for our time and for more complete and accurate readings. From his understanding of the unique role of sage wisdom—where knowledge, listening, and contact with the supernatural and heavenly world collide—Muller empowers readers to work through challenges in a constantly fluid state, securing favorable outcomes by properly aligning with each moment of change. This book also explains the concepts that are culturally embedded in the Chinese understanding of this system of guidance, giving readers greater confidence in their interpretation of how the hexagrams respond to their questions. Integrating the I Ching’s lessons will elevate your inner guidance so that, in time, you become capable of sensing the energetic shifts of each moment and can adapt to them effortlessly. When chaos overtakes order, the I Ching serves as a light to illuminate your way.

Här, i sin damm, trivs den lilla vattenödlan Molly och han kan inte tänka sig ett finare ställe. Men en dag utan förvarning, inträffar en förändring i hans omgivning, och han blir snabbt medveten om att han också påverkas. Bestämd att sätta stopp för förändringens framfart ger han sig ut på ett farligt och modigt äventyr.

Stellen sie sich vor, sie k nnten durch au ergew hnliche Umst nde auf einmal innerhalb von Sekunden reisen, wohin sie wollen, letztlich auch zu einem Fremden Planeten. Dort lernen sie die Au erirdischen kennen, die ihnen das erm glichen. Sie sind friedlich und uns in ihrer Entwicklung weit voraus. Wie k me die Menschheit damit klar, zudem noch ein Angebot zur Besiedlung des Planeten Rieger gemacht wird.

When the SCION project started in 2009, the goal was to create an architecture offering high availability and security for basic point-to-point communication. In the five years since the publication of SCION: A Secure Internet Architecture, this next-generation Internet architecture has evolved in terms of both design and deployment.On the one hand, there has been development of exciting new concepts and systems, including a new global time-synchronization system, an inter-domain approach for bandwidth reservations called COLIBRI, and Green Networking, which allows combating global climate change on three fronts. On the other hand, SCION is now also in production use by the Swiss financial ecosystem, and enables participants such as the Swiss National Bank, the Swiss provider of clearing services (SIX), and all Swiss financial institutes to communicate securely and reliably with each other via the Secure Swiss Finance Network.This unique guidebook provides an updated description of SCION's main components, covering new research topics and the most recent deployments. In particular, it presents in-depth discussion of formal verification efforts. Importantly, it offers a comprehensive, thorough description of the current SCION system:Describes the principles that guided SCION's design as a secure and robust Internet architectureProvides a comprehensive description of the next evolution in the way data finds its way through the InternetExplains how SCION can contribute to reducing carbon emissions, by introducing SCION Green NetworkingDemonstrates how SCION not only functions in academic settings but also works in production deploymentsDiscusses additional use cases for driving SCION's adoptionPresents the approaches for formal verification of protocols and code Illustrated with many colorful figures, pictures, and diagrams, allowing easy access to the concepts and use cases Assembled by a team with extensive experience in the fields of computer networks and security, this text/reference is suitable for researchers, practitioners, and graduate students interested in network security. Also, readers with limited background in computer networking but with a desire to know more about SCION will benefit from an overview of relevant chapters in the beginning of the book.

Our time is characterized by an explosive growth in the use of ever more complicated and sophisticated (computer) models. These models rely on dynamical systems theory for the interpretation of their results and on probability theory for the quantification of their uncertainties. A conscientious and intelligent use of these models requires that both these theories are properly understood. This book is to provide such understanding. It gives a unifying treatment of dynamical systems theory and probability theory. It covers the basic concepts and statements of these theories, their interrelations, and their applications to scientific reasoning and physics. The book stresses the underlying concepts and mathematical structures but is written in a simple and illuminating manner without sacrificing too much mathematical rigor. The book is aimed at students, post-docs, and researchers in the applied sciences who aspire to better understand the conceptual and mathematical underpinnings of the models that they use. Despite the peculiarities of any applied science, dynamics and probability are the common and indispensable tools in any modeling effort. The book is self-contained, with many technical aspects covered in appendices, but does require some basic knowledge in analysis, linear algebra, and physics. Peter Müller, now a professor emeritus at the University of Hawaii, has worked extensively on ocean and climate models and the foundations of complex system theories.

When the SCION project started in 2009, the goal was to create an architecture offering high availability and security for basic point-to-point communication. In the five years since the publication of SCION: A Secure Internet Architecture, this next-generation Internet architecture has evolved in terms of both design and deployment.On the one hand, there has been development of exciting new concepts and systems, including a new global time-synchronization system, an inter-domain approach for bandwidth reservations called COLIBRI, and Green Networking, which allows combating global climate change on three fronts. On the other hand, SCION is now also in production use by the Swiss financial ecosystem, and enables participants such as the Swiss National Bank, the Swiss provider of clearing services (SIX), and all Swiss financial institutes to communicate securely and reliably with each other via the Secure Swiss Finance Network.This unique guidebook provides an updated description of SCION's main components, covering new research topics and the most recent deployments. In particular, it presents in-depth discussion of formal verification efforts. Importantly, it offers a comprehensive, thorough description of the current SCION system:Describes the principles that guided SCION's design as a secure and robust Internet architectureProvides a comprehensive description of the next evolution in the way data finds its way through the InternetExplains how SCION can contribute to reducing carbon emissions, by introducing SCION Green NetworkingDemonstrates how SCION not only functions in academic settings but also works in production deploymentsDiscusses additional use cases for driving SCION's adoptionPresents the approaches for formal verification of protocols and code Illustrated with many colorful figures, pictures, and diagrams, allowing easy access to the concepts and use cases Assembled by a team with extensive experience in the fields of computer networks and security, this text/reference is suitable for researchers, practitioners, and graduate students interested in network security. Also, readers with limited background in computer networking but with a desire to know more about SCION will benefit from an overview of relevant chapters in the beginning of the book.

Hunderttausende Kinder und Lehrer werden auch in diesem Winter frieren, weil aus Hygienegründen die Fenster geöffnet werden müssen. Aber nicht nur das COVID-19-Virus ist Ursache für die Schullüftungsproblematik. Auch die Belastung der Atemluft durch weitere Luftinhaltstoffe, insbesondere durch CO2, kann negative Folgen für die Gesundheit haben und Konzentrationsmängel und Müdigkeit verursachen.

Der Kolosserbrief ist ein wichtiges Dokument aus der Zeit des fruhen Christentums. Er - ermoglicht einen wichtigen Einblick in die sowohl theologische als auch organisatorische Entwicklung fruher christlicher Gemeinden in Kleinasien;- lasst erkennen, wie die paulinische Verkundigung bewahrt und weiterentwickelt wird;- setzt theologische Impulse, die in der Folgezeit und bis in die Gegenwart immer wieder aufgegriffen und diskutiert werden;- wirkt mit etlichen seiner Formulierungen sprach- und stilbildend; - wirft allerdings im Detail viele Fragen auf, die kontrovers behandelt werden, nicht zuletzt die Verfasserfrage, die bis heute unterschiedlich beantwortet wird;- wartet schliesslich mit einigen Aussagen auf, die in Kirche und Gesellschaft umstritten sind. Peter Muller geht diesen Fragen detailliert nach und interpretiert den Kolosserbrief als ein von der Theologie des Paulus beeinflusstes und zugleich weiterfuhrendes Schreiben aus der formativen Zeit fruher christlicher Gemeinden.

Our time is characterized by an explosive growth in the use of ever more complicated and sophisticated (computer) models. These models rely on dynamical systems theory for the interpretation of their results and on probability theory for the quantification of their uncertainties. A conscientious and intelligent use of these models requires that both these theories are properly understood. This book is to provide such understanding. It gives a unifying treatment of dynamical systems theory and probability theory. It covers the basic concepts and statements of these theories, their interrelations, and their applications to scientific reasoning and physics. The book stresses the underlying concepts and mathematical structures but is written in a simple and illuminating manner without sacrificing too much mathematical rigor. The book is aimed at students, post-docs, and researchers in the applied sciences who aspire to better understand the conceptual and mathematical underpinnings of the models that they use. Despite the peculiarities of any applied science, dynamics and probability are the common and indispensable tools in any modeling effort. The book is self-contained, with many technical aspects covered in appendices, but does require some basic knowledge in analysis, linear algebra, and physics. Peter Müller, now a professor emeritus at the University of Hawaii, has worked extensively on ocean and climate models and the foundations of complex system theories.

I denne bog sættes der fokus på de valg og udfordringer, som det indebærer at undervise i matematik på de mindste klassetrin. Bogen bygger på et matematikdidaktisk teoretisk grundlag, hvor teori og praktiske eksempler giver ideer til, hvordan man kan arbejde med den gode matematikundervisning i indskolingen.Bogen indeholder følgende kapitler:- Hvordan lærer børn at forstå tal?- Subtraktion- Addition, multiplikation og division- De gode spørgsmål- Matematik i den magiske cirkel- Geometri- Statistik

Es gibt bisher kaum allgemeinverständliche, umfassende Informationen zum Thema Wohnungslüftung, obwohl mit dem Einsatz erhebliche Vorteile verbunden sind: Gesunde Raumluft und Energieeinsparung. Aktuell wird die Technik immer interessanter. Das Buch will umfassend über Vor- und Nachteile und die technischen Zusammenhänge informieren und Ratgeber sein.Sich Wohlfühlen mit kontrollierter Wohnungslüftung. Gibt es Probleme? Was bewirkt ein Lüftungskonzept? Wie finde ich das für mich passende Lüftungssystem? Was wird gefördert? Wie geht man vor, bei der Anlagenplanung und bei der Installation? Was ist beim Betrieb einer Wohnungslüftungsanlage zu beachten?