Siddhartha Mukherjee

Spanning the globe and several centuries, this is the story of the quest to decipher the master-code that makes and defines humans, that governs our form and function. It is also an intimate history of the author's own family and its recurring pattern of mental illness, reminding us that genetics is vitally relevant to everyday lives.

WINNER OF THE GUARDIAN FIRST BOOK AWARD 2011 WINNER OF THE PULITZER PRIZE FOR NON-FICTION 2011 ‘Profound, eloquent and searching’ SUNDAY TIMES ‘Essential reading’ INDEPENDENT ‘Masterly’ GUARDIAN ‘Extraordinary’ NEW YORK TIMES BOOK REVIEW Riveting, audacious and now more urgent than ever in this vast update, The Emperor of All Maladies is a masterpiece. The story of cancer is a human one – a tale of chance discoveries, seized opportunities and human endurance. From innovative early surgeries to the Curies’ ultimately tragic work with radiation; from Sidney Farber’s hugely risky discovery of chemotherapy to the author’s treatment of his own patients, The Emperor of All Maladies is a profound and revelatory portrait of an enigmatic disease humans have lived with, and perished from, for more than five thousand years. In this updated edition of Siddhartha Mukherjee’s instant classic, four new chapters reveal what has changed in the universe of cancer in the years since the book was first published. With moving eloquence, he offers an insight into our evolving understanding of cancer’s causes and the emerging, revolutionary new treatments that might shape its future, including those that Mukherjee himself has helped devise. ‘This elegantly written overview allows us to look a once whispered-about illness squarely in the eye’ INDEPENDENT ‘The notion of "popular science" doesn't come close to describing this achievement. It is literature’ OBSERVER

WINNER OF THE PULITZER PRIZE * A NEW YORK TIMES TOP 100 BOOK OF THE CENTURY * A NEW YORK TIMES BOOK REVIEW BEST BOOK OF THE YEAR * A TIME ALL-TIME 100 NONFICTION BOOK Updated with FOUR NEW MAJOR CHAPTERS illuminating the new developments in cancer detection, prevention, treatment, and understanding in the fifteen years since the book's first publication, this New York Times bestseller is "an extraordinary achievement" (The New Yorker)--a magnificent, profoundly humane "biography" of cancer. Siddhartha Mukherjee's The Emperor of All Maladies became an instant classic when it was published in 2010. A magnificent, humane "biography" of cancer--from its first documented appearances thousands of years ago through the epic 20th century to cure, control, and conquer it to a radical new understanding of its essence--The Emperor of All Maladies is one of the most highly acclaimed books of its time. In the years since Mukherjee dazzled readers with The Emperor of All Maladies, much has changed in the universe of cancer--in our understanding of its causes; in our attempts to prevent it; and in the revolutionary new treatments. In four profound and revelatory new chapters--essentially a new book about cancer--he illuminates this disease with both a bird's eye view of the landscape and an acute focus on the role of the cell. He also looks at imminent new studies--and to the future. Riveting, audacious, and now more urgent than ever in this vast update, The Emperor of All Maladies is a masterpiece.

The book provides the whole horizon of process engineering and plant design from concept phase through the execution to commissioning of the plant in the real practice. Providing a complete industrial perspective, the book:Covers the guidelines and standards followed in the industry and how engineering documents are generated using these standardsDescribes Hazardous Area Classification, Relief System Design, Revamp Engineering, Interaction with Other Disciplines, and Pre-commissioning and CommissioningContains several illustrated practical examples, which clarify the fundamentals to a raw chemical engineerIncludes description of a complete chemical project from concept to commissioningTreating the topic from the perspective of an industrial employee with extensive experience in process engineering and plant design, it aims to aid chemical and plant engineers to deal with decision making processes on strategic level, management tasks and leading functions beside the technical know-how.

Onkolog Siddkhartkha Mukerdzhi nagljadno, zhivym jazykom i pri pomoschi dostupnykh metafor objasnjaet neverojatnuju slozhnost kletochnykh vzaimodejstvij v organizme, rasskazyvaet ob istorii meditsiny i ob evoljutsii vosprijatija chelovecheskogo tela v nauke: ot tselostnogo konstrukta k "zdaniju", sobrannomu iz besschetnogo mnozhestva otdelnykh i nezavisimykh "kirpichikov", i k slozhnoj sisteme, rozhdennoj iz plotnogo vzaimodejstvija etikh kirpichikov. O tom, kak ponimanie imenno etogo vzaimodejstvija tait v sebe kljuch k ponimaniju nashej fiziologii i kak ego narushenie vlechet za soboj vse izvestnye nauke patologii.

I slutet av 1600-talet tittar den engelske vetenskapsmannen Hooke och den holländske forskaren Leeuwenhoek ner i sina enkla, handgjorda mikroskop, oberoende av varandra. Vad de ser ska revolutionera biologin och läkekonsten för alltid. Dessa livets elementarpartiklar – cellerna – medförde en ny förståelse för vad det innebär att vara människa, och vad det skulle kunna komma att innebära i framtiden.Två hundra år senare kunde den tyske läkaren Rudolf Virchow underkänna populära föreställningar om att kroppsvätskor, psykiska avvikelser, hysteri, neuroser eller miasma – eller Guds vilja, för den delen – orsakade sjukdom. Vetenskapen började betrakta människokroppen som ett ekosystem av celler. Alla celler kommer ur andra celler; normal fysiologi är en funktion av cellfysiologi; sjukdom, störningar i fysiologin, är följden av störningar i cellens fysiologi.Siddhartha Mukherjee är bästsäljande populärvetenskaplig författare och en av vår tids mest framstående cellforskare. Cellernas sång är den spektakulära berättelsen om människorna som upptäckte cellen, lärde sig förstå den, reparera den och manipulera den.

Eta epokhalnaja kniga - vseobemljuschaja, zhivo izlozhennaja i gluboko obosnovannaja nauchno istorija otnoshenij chelovechestva i raka, na fone kotoroj razvorachivajutsja lichnye istorii vojny s "tsarem vsekh boleznej". Provodja chitatelja cherez izmenchivye predstavlenija ob etoj bolezni v raznye epokhi, sposoby lechenija, vekhi poznanija ee mekhanizmov i konflikty interesov vokrug nee, avtor raskryvaet prichiny ogranichennosti pobed nad nej i namechaet realistichnye kontury sosuschestvovanija s nej v buduschem. Izvechnym mechtam o volshebnoj piljule ot raka na stranitsakh knigi protivostoit vrag, stol kovarnyj potomu, chto slishkom napominaet v svoem biologicheskom sovershenstve iskazhennye otrazhenija nas samikh. Pjat prichin kupit 1 Siddkhartkha Mukerdzhi - amerikanskij vrach-onkolog indijskogo proiskhozhdenija, vypusknik Stenfordskogo i Oksfordskogo universitetov, dotsent meditsinskikh nauk v Kolumbijskom universitete. 2 V etom zakhvatyvajuschem meditsinskom trillere opisyvaetsja istorija raka - ot pervykh upominanij bolezni v drevnikh istochnikakh do lichnykh istorij patsientov, zhivuschikh i borjuschikhsja s rakom v nashe vremja. 3 Kniga budet interesna ne tolko vracham i spetsialistam v oblasti biologii i meditsiny, no i vsem, kto khotel by bolshe uznat o sovremennykh issledovanijakh i metodakh lechenija etoj bolezni. 4 V 2011 godu kniga "Tsar vsekh boleznej" byla udostoena Pulittserovskoj premii, a zhurnal Time pomestil rabotu Mukerdzhi v spisok sta luchshikh nekhudozhestvennykh knig s 1923 goda. 5 Drugaja kniga Mukerdzhi "Gen. Ochen lichnaja istorija" stala mirovym bestsellerom.Perevodchik: Vinogradova Marija

**Longlisted for the Baillie Gifford Prize 2023**A NEW YORK TIMES, DAILY TELEGRAPH, ECONOMIST, MAIL ON SUNDAY and GUARDIAN BOOK OF THE YEARFrom the dawn of life itself, every being that has ever lived owes its existence to the cell.'Will leave you in awe' GuardianThe discovery of this vital form led to a transformation in medicine but also in our understanding of ourselves - not as bodies or machines but as ecosystems. It has also given us the power to treat a vast array of mortal maladies...and even to create new kinds of human altogether.Rich with stories of scientists, doctors and the patients whose lives may be saved by their work, The Song of the Cell is a stunning ode to the building blocks of life and the cutting-edge science harnessing their power for the better.'Profound...As big a topic as life itself' The Times'Medical magic' Daily Telegraph'Vast...important...optimistic' Mail on Sunday

«En un relato a la vez l rico y amplio, Mukherjee nos lleva a trav s de una historia de la comprensi n humana: desde el descubrimiento en el siglo XVII de que estamos formados por c lulas hasta la actual tecnolog a de vanguardia para manipular y desplegar c lulas con fines terap uticos . The New Yorker Tras los xitos de El emperador de todos los males y El gen, Siddhartha Mukherjee se adentra en la incre ble y apasionante historia de la c lula. Bienvenidos a la apasionante historia de la c lula. En este nuevo libro, el onc logo y divulgador Siddhartha Mukherjee nos acompa a en un viaje fascinante a partir de uno de los mayores descubrimientos cient ficos de la historia: el hecho de que todos los organismos vivos complejos est n constituidos por unidades diminutas, aut nomas y autorreguladas, esas que en el siglo XVII Robert Hooke vio a trav s de su microscopio y bautiz con el nombre que hoy conocemos. Aquel hallazgo, seguido de una cada vez mejor comprensi n de la fisiolog a celular cambi para siempre (y a n determina) la manera en que abordamos la medicina, la ciencia, la biolog a, las estructuras sociales y hasta la cultura. Una fractura de cadera, una parada cardiaca, el Alzheimer, el sida, un c ncer de pulm n... todo, absolutamente todo, puede explicarse como el resultado del funcionamiento an malo de las c lulas o de los ecosistemas que estas forman. Y tambi n todo deber a poder tratarse mediante su manipulaci n terap utica. Esta revoluci n en el campo de la biolog a celular ya ha demostrado resultados transformadores y hoy se plantea como uno de los avances cient ficos que m s vidas pueden salvar. ENGLISH DESCRIPTION Winner of the 2023 PROSE Award for Excellence in Biological and Life Sciences Named a New York Times Notable Book and a Best Book of the Year by The Economist, Oprah Daily, BookPage, Book Riot, the New York Public Library, and more In The Song of the Cell, the extraordinary author of the Pulitzer Prize-winning The Emperor of All Maladies and the #1 New York Times bestseller, The Gene, "blends cutting-edge research, impeccable scholarship, intrepid reporting, and gorgeous prose into an encyclopedic study that reads like a literary page-turner" (Oprah Daily). Mukherjee begins this magnificent story in the late 1600s, when a distinguished English polymath, Robert Hooke, and an eccentric Dutch cloth-merchant, Antonie van Leeuwenhoek, looked down at their handmade microscopes. What they saw introduced a radical concept that swept through biology and medicine, touching virtually every aspect of the two sciences, and altering both forever. It was the fact that complex living organisms are assemblages of tiny, self-contained, self-regulating units. Our organs, our physiology, our selves--hearts, blood, brains--are built from these compartments. Hooke christened them "cells." The discovery of cells--and the reframing of the human body as a cellular ecosystem--announced the birth of a new kind of medicine based on the therapeutic manipulations of cells. A hip fracture, a cardiac arrest, Alzheimer's dementia, AIDS, pneumonia, lung cancer, kidney failure, arthritis, COVID pneumonia--all could be reconceived as the results of cells, or systems of cells, functioning abnormally. And all could be perceived as loci of cellular therapies. Filled with writing so vivid, lucid, and suspenseful that complex science becomes thrilling, The Song of the Cell tells the story of how scientists discovered cells, began to understand them, and are now using that knowledge to create new humans. Told in six parts, and laced with Mukherjee's own experience as a researcher, a doctor, and a prolific reader, The Song of the Cell is both panoramic and intimate--a masterpiece on what it means to be human. "In an account both lyrical and capacious, Mukherjee takes us through an evolution of human understanding: from the seventeenth-century discovery that humans are made up of cells to our cutting-edge technologies for manipulating and deploying cells for therapeutic purposes" (The New Yorker).

Winner of the 2023 PROSE Award for Excellence in Biological and Life Sciences and the 2023 Chautauqua Prize Named a New York Times Notable Book and a Best Book of the Year by The Economist, Oprah Daily, BookPage, Book Riot, the New York Public Library, and more In The Song of the Cell, the extraordinary author of the Pulitzer Prize-winning The Emperor of All Maladies and the #1 New York Times bestseller The Gene "blends cutting-edge research, impeccable scholarship, intrepid reporting, and gorgeous prose into an encyclopedic study that reads like a literary page-turner" (Oprah Daily). Mukherjee begins this magnificent story in the late 1600s, when a distinguished English polymath, Robert Hooke, and an eccentric Dutch cloth-merchant, Antonie van Leeuwenhoek looked down their handmade microscopes. What they saw introduced a radical concept that swept through biology and medicine, touching virtually every aspect of the two sciences, and altering both forever. It was the fact that complex living organisms are assemblages of tiny, self-contained, self-regulating units. Our organs, our physiology, our selves--hearts, blood, brains--are built from these compartments. Hooke christened them "cells." The discovery of cells--and the reframing of the human body as a cellular ecosystem--announced the birth of a new kind of medicine based on the therapeutic manipulations of cells. A hip fracture, a cardiac arrest, Alzheimer's dementia, AIDS, pneumonia, lung cancer, kidney failure, arthritis, COVID pneumonia--all could be reconceived as the results of cells, or systems of cells, functioning abnormally. And all could be perceived as loci of cellular therapies. Filled with writing so vivid, lucid, and suspenseful that complex science becomes thrilling, The Song of the Cell tells the story of how scientists discovered cells, began to understand them, and are now using that knowledge to create new humans. Told in six parts, and laced with Mukherjee's own experience as a researcher, a doctor, and a prolific reader, The Song of the Cell is both panoramic and intimate--a masterpiece on what it means to be human. "In an account both lyrical and capacious, Mukherjee takes us through an evolution of human understanding: from the seventeenth-century discovery that humans are made up of cells to our cutting-edge technologies for manipulating and deploying cells for therapeutic purposes" (The New Yorker).

The book provides the whole horizon of process engineering and plant design from concept phase through the execution to commissioning of the plant in the real practice. Providing a complete industrial perspective, the book:Covers the guidelines and standards followed in the industry and how engineering documents are generated using these standardsDescribes Hazardous Area Classification, Relief System Design, Revamp Engineering, Interaction with Other Disciplines, and Pre-commissioning and CommissioningContains several illustrated practical examples, which clarify the fundamentals to a raw chemical engineerIncludes description of a complete chemical project from concept to commissioningTreating the topic from the perspective of an industrial employee with extensive experience in process engineering and plant design, it aims to aid chemical and plant engineers to deal with decision making processes on strategic level, management tasks and leading functions beside the technical know-how.

On 11 March 2020, the WHO declared we were in a pandemic. Covid-19 was tearing through the world at an alarming rate and little was actually known about it, let alone how to treat it. The majority of us had paid little attention to the development of a new strain of coronavirus in China earlier on in the year; however, on 4 January 2020 Justin Stebbing, Professor of Cancer Medicine and Oncology at Imperial College London, wrote an email to Niall Ferguson mentioning stories he had heard of strange cases of pneumonia emanating from Wuhan, China. He then began writing daily notes. In Witness to Covid: 2020, Professor Justin Stebbing tracks the development of Covid-19 over the course of this unforgettable year, navigating his way through the infodemic of misinformation regarding the virus. From the early onset of this novel coronavirus when he tracked its spread and tried to learn more about it, the impact on individual countries and the search for treatment, through to the development of vaccines, their clinical trials and eventual rollout, and the emergence of newly developing variants. This book takes a unique look at a truly unique year.

Hva er tidenes viktigste detektivhistorie? Fortellingen om menneskenes kamp for avsløre hemmeligheten om oss selv - koden som forteller hva som gjør oss til mennesker. Hva skjer når vi mennesker nå er i stand å «lese» og «skrive» den koden selv - og dermed forme og forandre skjebnen til våre barn, deres barn og etterkommere igjen, potensielt sett til hele menneskeheten? Knapt noe felt innen medisinen og naturvitenskapene har større betydning for våre liv og vår framtid i dag enn genetikken. Likevel kjenner de færreste mer enn bare biter av de enorme oppdagelsene som skjer på feltet hvert eneste år - og nesten ingen er i stand til å forklare genetikkens grunnleggende prinsipper og mekanismer. Med Gener har medisineren og Pulitzer-vinneren Siddharta Mukherjee gitt oss en lysende klartenkt og samtidig intenst spennende framstilling av genetikkens historie fra de gamle grekerne fram til det som kanskje er nåtidens største vitenskapelige revolusjon: oppdagelse av det menneskelige genomet. Mukherjee gir liv til menneskenes tusenårlange søken etter å finne nøklene til vår egen arvelighet, lyser opp genetikkens innfløkte og komplekse problemer - og viser hvordan vitenskapens oppdagelser påvirker våre liv, personligheter, skjebne og valg. Gjennom hele framstillingen er Mukherjees egen familie og dens tragiske og forvirrende kamp med schizofreni og psykiske sykdommer flettet inn - som en påminnelse om hvordan arvelighetens gåter former oss, og griper inn i alle våre liv. Gener er en unik litterær formidlingsbragd - og obligatorisk lesing for alle som er opptatt av menneskenes vesen og framtid. Dette er samtidens aller mest avgjørende spørsmål - gjenfortalt og forklart av en sann litterær mester.

Pulitzer-palkittu kirjailija ja syöpälääkäri Siddhartha Mukherjee kertoo geenin tarinan perinpohjaisesti mutta lennokkaasti. Kirja lähtee liikkeelle Mendelin hernetarhasta ja päätyy moninaisten vaiheiden kautta nykyisiin geenimuokkausmenetelmiin yrittäessään selvittää arvoituksellista koodia, joka tekee meistä ihmisiä.Kirja kertoo samalla hyvin intiimin ja henkilökohtaisen tarinan, kun intialaissyntyinen Mukherjee tutkii oman sukunsa skitsofreniaa ja sen perinnöllisyyttä.Mukherjee nostaa kirjassaan esiin geenitutkimukseen liittyviä filosofisia ja eettisiä kysymyksiä. Oman osansa saavat niin rotuhygienia, kantasolututkimus kuin geeniperimän vaikutus yksilön terveyteen. Hän törmää koko ajan myös kysymykseen siitä, mikä oikeastaan on ”luonnollista”.Siddhartha Mukherjee on Pulitzer-palkittu kirjailija ja lääketieteen professori Columbian yliopistossa. Hänen kirjansa "Sairauksien keisari: Syövän elämäkerta" on julkaistu suomeksi vuonna 2016.