Tilman Grune

Das Essential behandelt in leicht verständlicher, komprimierter Weise die Grundlagen altersbedingter Zellveränderungen, die unter Umständen zur Neurodegeneration führen können. Der Autor erläutert, wie der Alterungsprozess und die Neurodegeneration durch oxidativen Stress und dabei entstehende Schäden beeinflusst werden. Unter diesen Schäden nimmt die Bildung von Proteinaggregaten, die hier besonders ausführlich beschrieben werden, eine Schlüsselstellung ein. Darüber hinaus werden einige Aspekte der Ernährung im Alter und ihre möglichen Auswirkungen auf die Entstehung von neurodegenerativen Erkrankungen vorgestellt.

Reviews our current understanding of the role of protein oxidation in aging and age-related diseases Protein oxidation is at the core of the aging process. Setting forth a variety of new methods and approaches, this book helps researchers conveniently by exploring the aging process and developing more effective therapies to prevent or treat age-related diseases. There have been many studies dedicated to the relationship between protein oxidation and age-related pathology; now it is possible for researchers and readers to learn new techniques as utilizing protein oxidation products as biomarkers for aging. Protein Oxidation and Aging begins with a description of the tremendous variety of protein oxidation products. Furthermore, it covers: Major aspects of the protein oxidation processCellular mechanisms for managing oxidized proteinsRole of protein oxidation in agingInfluence of genetic and environmental factors on protein oxidationMeasuring protein oxidation in the aging processProtein oxidation in age-related diseases References at the end of each chapter serve as a gateway to the growing body of original research studies and reviews in the field.