Amit Kumar

La toxine botulique est la substance la plus toxique connue. Un seul gramme de toxine cristalline, dispers uniform ment et inhal , tuerait plus d'un million de personnes, bien que des facteurs techniques rendent cette diss mination difficile. La base de la puissance ph nom nale de la toxine botulique est enzymatique: la toxine est une prot inase de zinc qui clive une ou plusieurs des prot ines de fusion par lesquelles les v sicules neuronales lib rent l'ac tylcholine dans la jonction neuromusculaire. Elle est devenue la premi re toxine biologique tre autoris e pour le traitement de maladies humaines. La toxine botulique est actuellement autoris e pour le traitement du torticolis cervical, du strabisme et du bl pharospasme associ la dystonie.

Botulinumtoxin ist der giftigste bekannte Stoff. Ein einziges Gramm kristallines Toxin, gleichm ig verteilt und eingeatmet, w rde mehr als 1 Million Menschen t ten, obwohl technische Faktoren eine solche Verbreitung erschweren w rden. Das Toxin ist eine Zinkproteinase, die eines oder mehrere der Fusionsproteine spaltet, durch die neuronale Bl schen Acetylcholin in die neuromuskul re Verbindung freisetzen. Es ist das erste biologische Toxin, das f r die Behandlung menschlicher Krankheiten zugelassen wurde. Botulinumtoxin ist derzeit f r die Behandlung von zervikalem Schiefhals, Strabismus und Blepharospasmus in Verbindung mit Dystonie zugelassen.

La tossina botulinica la sostanza pi velenosa conosciuta. Un singolo grammo di tossina cristallina, disperso uniformemente e inalato, ucciderebbe pi di 1 milione di persone, anche se fattori tecnici renderebbero difficile tale diffusione. La base della fenomenale potenza della tossina botulinica enzimatica: la tossina una zinco-proteinasi che scinde 1 o pi delle proteine di fusione con cui le vescicole neuronali rilasciano acetilcolina nella giunzione neuromuscolare. diventata la prima tossina biologica ad essere autorizzata per il trattamento di malattie umane. La tossina botulinica attualmente autorizzata per il trattamento del torcicollo cervicale, dello strabismo e del blefarospasmo associato alla distonia.

A toxina botul nica a subst ncia mais venenosa conhecida. Uma nica grama de toxina cristalina, uniformemente dispersa e inalada, mataria mais de 1 milh o de pessoas, embora factores t cnicos dificultassem essa dissemina o. A base da pot ncia fenomenal da toxina botul nica enzim tica a toxina uma proteinase de zinco que cliva 1 ou mais das prote nas de fus o atrav s da qual as ves culas neuronais liberam acetilcolina na jun o neuromuscular. Ela se tornou a primeira toxina biol gica a ser licenciada para o tratamento de doen as humanas. A toxina botul nica est atualmente licenciada para o tratamento de torcicolo cervical, estrabismo e blefaroespasmo associado distonia.

This book introduces readers to the fundamentals of transportation problems under the fuzzy environment and its extensions. It also discusses the limitations and drawbacks of (1) recently proposed aggregation operators under the fuzzy environment and its various extensions; (2) recently proposed methods for solving transportation problems under the fuzzy environment; and (3) recently proposed methods for solving transportation problems under the intuitionistic fuzzy environment. In turn, the book proposes simplified methods to overcome these limitations.

Yeh Kavita Sangrah saamaajik bhavnaaon aur vicharon ka shabdchitra prastut krta hai.Saamaajik paristhitiyon me manushya ke vicharon tatha krityon me amoolchool parivartan dekhne ko mila hai.Unhi badlaawon ko rekhankit karta yeh kavita sangrah unhi dweshpurna aachranon pr chot karta hai .Yeh kavita sangrah samaaj ke un vargon ka gungaan bhi krta hai jo aaj bhi apne daayitwon ko nishtha se nibha rhe hain.

Il campo della protesica ha fatto molta strada dalla semplice sostituzione dei denti mancanti con la semplice meccanica dell'era sconfinata della tecnologia moderna. Uno di questi progressi tecnologici l'introduzione dei laser nel campo della protesica che ha sostituito molte procedure chirurgiche e tecniche convenzionali e sta cominciando a sostituire il manipolo dentale. La capacit dell'energia laser nella decontaminazione batterica sembra porre il suo uso al di sopra di quello di altre modalit . Questo libro fornisce una breve conoscenza dei laser in prostodonzia.

Der Bereich der Prothetik hat einen langen Weg vom einfachen Ersatz fehlender Z hne durch einfache Mechanik in der grenzenlosen ra der modernen Technologie zur ckgelegt. Ein solcher technologischer Fortschritt ist die Einf hrung des Lasers im Bereich der Prothetik, der viele konventionelle chirurgische und technische Verfahren ersetzt hat und dabei ist, das zahn rztliche Handst ck zu ersetzen. Dieses Buch vermittelt ein kurzes Wissen ber Laser in der Prothetik.

Pole protetyki przeszedl dlugą drogę od po prostu zastępując brakujące zęby przez proste mechaniki bezgranicznej erze nowoczesnych technologii. Jednym z takich postęp w technologicznych jest wprowadzenie laser w w dziedzinie protetyki, kt ry zastąpil wiele konwencjonalnych procedur chirurgicznych i technicznych i zaczyna zastępowac dentystyczne hand piece.The zdolnośc energii laserowej w bakteryjnej dekontaminacji wydaje się umieścic jego stosowania powyżej, że z innych modalności. Książka ta dostarcza kr tkiej wiedzy na temat laser w w protetyce.

O campo da protodontia evoluiu muito desde a simples substitui o de dentes ausentes pela mec nica simples da era sem limites da tecnologia moderna. Um desses avan os tecnol gicos a introdu o dos lasers no campo da pr tese que substituiu muitos procedimentos cir rgicos e t cnicos convencionais e est come ando a substituir a pe a de m o dental. Este livro fornece um breve conhecimento sobre os lasers em Dentisteria Prot tica.

Le domaine de la prosthodontie a parcouru un long chemin depuis le remplacement des dents manquantes par de simples m canismes de l' re illimit e de la technologie moderne. L'une de ces avanc es technologiques est l'introduction du laser dans le domaine de la prosthodontie, qui a remplac de nombreuses proc dures chirurgicales et techniques conventionnelles et qui commence remplacer la pi ce main dentaire. Ce livre fournit une br ve connaissance des lasers en prosthodontie.

Majority of the people in India are still engaged in agriculture and irrigation plays an important role in terms of enhancing the productivity of the sector along with other inputs. This books present the trends and patterns relating to irrigation infrastructure development in India since the early 1970s. It brings attention to the various issues plaguing the different sources of irrigation. It further explores the equity aspects in terms of access to different sources of irrigation among different categories of farm holdings.

High compressibility and low shear strength of expansive soil stimulate the substantial distress and excessive settlement of overlying structures and pavements; and requires proper soil stabilisation before commencing any construction on it. Advancement in this direction provides variety of soil improvement solutions like soil replacement, dynamic compaction, lime/cement columns, stone columns and usage of fibrous materials for soil reinforcement. The present study demonstrates the efficacy of polypropylene fibres (PPF) as an additive to stabilise the expansive soil. Statically compacted virgin and PPF (6mm and 12mm) admixed (0.05%-0.25% having constant leap of 0.05%) soil specimens have been prepared for the experimentation. Unconfined compressive strength (UCS) and One-dimensional consolidation tests have been performed to assess the strength and compressibility characteristics of the virgin and remolded soil specimens of expansive soil. Experimental results manifest not only an increasing trend for UCS with the percentage increase of both sized fibres separately but also for strain at failure. Ultimately, improve the tensile behaviour of the subjected soil. A noticeable decrease in compression index and degree of consolidation both was also found after incorporating the fibres in the soil specimens. So, the present study route the fibres for a potential application in various geotechnical fields.