Deepak Kumar

Das Szenario der Forschung war die Entwicklung eines Polymermatrix-Diffusionskontrollierten transdermalen Wirkstoffabgabesystems, das den Wirkstoff Telmisartan mit einem unterschiedlichen Verh ltnis von hydrophilem (HPMC) und lipophilem (EC, Eudragit RS 100) Polymersystem durch L sungsmittelgie technik auf Aluminiumfolie enth lt, wobei 30% w/v Dibutylphthalat des Polymergewichts als Weichmacher und 20% w/v, 30% w/v Dimethylsulfoxid (Polymergewicht) als Permeationsverst rker f r die transdermale Wirkstofffreisetzung verwendet wurden. Insgesamt neun Formulierungen wurden unter Verwendung desselben Arzneimittels und verschiedener Polymeranteile entwickelt. Alle transdermalen Pflaster wurden physikochemisch bewertet: Dicke, Gewichtsvariation, prozentuale Feuchtigkeitsaufnahme, prozentualer Feuchtigkeitsverlust, Faltfestigkeit, Flachheit, Wirkstoffgehalt und prozentuale Wirkstofffreisetzung. . Die In-vitro-Permeationsstudie wurde mit Diffusionszellen durchgef hrt. Die maximale prozentuale Wirkstofffreisetzung in vitro wurde bis zu 48 Stunden mit der Formulierung F8 beobachtet, die HPMC: EC: Eudragit RS 100 im Verh ltnis (5:0:1) enth lt.

Munmun, More Than a mere Crush is a heartwarming tale of first love, friendship, and self-discovery set in the bustling city of Patna. It follows the journey of Romi, a brilliant yet shy boy who navigates the ups and downs of teenage life with dreams in his eyes and books in his hands. His world turns upside down when he crosses paths with Munmun-the girl who unknowingly becomes his first crush and his greatest distraction. Through humorous encounters, awkward conversations, and innocent confessions, Romi learns about love, longing, and letting go. The story beautifully captures the emotions of a young boy who, despite his academic brilliance, is just as clueless as any other teenager when it comes to matters of the heart. This book isn't just about Romi's affection for Munmun; it is about the memories that shape us, the friendships that support us, and the bittersweet feeling of growing up. With relatable characters and nostalgic moments, Munmun, More Than a mere Crush will take you back to your own teenage days-the time when even a smile could make your heart skip a beat. Dive into this journey of innocence, laughter, and love. Because sometimes, the first crush isn't just a memory-it's a story worth telling.

O objetivo da investiga o foi desenvolver um sistema de administra o transd rmica controlada por difus o de matriz polim rica contendo o f rmaco Telmisartan com diferentes propor es de sistema polim rico hidrof lico (HPMC) e lipof lico (EC, Eudragit RS 100) atrav s da t cnica de moldagem por solvente em folha de alum nio, utilizando 30% p/v de ftalato de dibutilo do peso polim rico, incorporado como plastificante e 20% p/v, 30% p/v de dimetilsulf xido (peso polim rico) como potenciador de permea o para a liberta o transd rmica do f rmaco. No total, foram desenvolvidas nove formula es utilizando o mesmo f rmaco e diferentes r cios de pol meros. Todos os adesivos transd rmicos foram avaliados do ponto de vista f sico-qu mico com a espessura, varia o de peso, % de absor o de humidade, % de perda de humidade, resist ncia dobragem, planicidade, teor de f rmaco e % de liberta o de f rmaco. . O estudo de permea o invitro foi efectuado por c lulas de difus o. A % m xima de liberta o de f rmaco foi observada at 48 horas com a formula o F8 contendo HPMC: EC: Eudragit RS 100 na propor o de (5:0:1).

Lo scenario della ricerca stato quello di sviluppare un sistema di rilascio transdermico di farmaci a matrice polimerica a diffusione controllata, contenente il farmaco Telmisartan con un diverso rapporto tra sistema polimerico idrofilo (HPMC) e lipofilo (EC, Eudragit RS 100), mediante la tecnica di colata con solvente su un foglio di alluminio, utilizzando il 30% w/v di Dibutyl Phthalate del peso polimerico, incorporato come plastificante e il 20% w/v, il 30% w/v di Dimethyl Sulfoxide (peso polimerico) stato utilizzato come potenziatore della permeazione per il rilascio transdermico del farmaco. In totale sono state sviluppate nove formulazioni, utilizzando lo stesso farmaco e diversi rapporti polimerici. Tutti i cerotti transdermici sono stati valutati dal punto di vista fisico-chimico con spessore, variazione di peso, % di assorbimento di umidit , % di perdita di umidit , resistenza alla piegatura, planarit , contenuto di farmaco e % di rilascio di farmaco. . Lo studio di permeazione invitro stato eseguito con celle di diffusione. Il rilascio massimo di farmaco in invitro stato osservato fino a 48 ore con la formulazione F8 contenente HPMC: EC: Eudragit RS 100 in rapporto (5:0:1).

Interrogating the notion of medical knowledge and public health practices in colonial India, this volume explores the complex encounters between Western medical systems and indigenous healing traditions during British rule. The book examines how colonial medical institutions functioned as instruments of both care and control, while indigenous practices retained their relevance among the masses. Through detailed case studies including W.M. Haffkine's plague vaccine campaigns, the Rockefeller Foundation's public health interventions, and the evolution of medical research under colonial constraints, the book reveals the multifaceted nature of medical encounters at various sites between 1820 and 1920. The analysis extends to examining the Indian Medical Gazette as a mirror reflecting contemporary medical debates, the contours of medical research in a colonial laboratory, and comparative perspectives from other colonies in Southeast Asia and East Africa. The work demonstrates how medical knowledge became a contested terrain where scientific advancement, colonial politics, and indigenous resistance intersected. This book will be of significant interest to historians of medicine, colonial studies scholars, public health professionals, sociologists, and policy planners seeking to understand the historical foundations of contemporary medical systems in South Asia. It offers valuable insights for postgraduate students and researchers in medical history, colonial history, public health, and South Asian studies.

Es wird erwartet, dass sich die Hydrologie und das hydrologische System der meisten Flusseinzugsgebiete aufgrund des Klimawandels ver ndern werden. Dieser ver nderte Wasserhaushalt wird es den Bewirtschaftern von Wasserressourcen erschweren, den Bedarf der wachsenden Bev lkerung, der empfindlichen kosysteme, der Landwirte, Viehz chter, Energieerzeuger und der Industrie zu decken. Der Klimawandel beeinflusst die Niederschlagsmuster und die Verteilung des Wassers weltweit. Eine geringere Anreicherung kann die Wasserqualit t verschlechtern. Steigende Oberfl chentemperaturen und Extremereignisse k nnen das Ausma und den Zeitpunkt des Abflusses beeinflussen und die Verdunstung erh hen. Daher ist es wichtig, vern nftige Anpassungsstrategien zu entwickeln, um die negativen Auswirkungen des Klimawandels auf die Wasserressourcen zu verringern und ihre nachhaltige Entwicklung zu gew hrleisten. Die vorliegende Studie zielt darauf ab zu verstehen, wie der Klimawandel die Hydrologie und die Wasserressourcen des Jatayu Ganga-Wassereinzugsgebiets im Kumaun Himalaya beeinflusst. Der Jatayu Ganga ist ein wichtiger regengespeister, nicht-glazialer Nebenfluss des Saryu-Flusses, dessen Wasserstand inzwischen in alarmierendem Ma e abnimmt.

Oczekuje się, że hydrologia i system hydrologiczny większości zlewni rzek ulegną zmianie z powodu zmian klimatycznych. Ten zmieniający się bilans wodny utrudni zarządzającym zasobami wodnymi sprostanie wymaganiom rosnącej populacji, wrażliwych ekosystem w, rolnik w, hodowc w, producent w energii i przemyslu. Zmiany klimatu wplywają na wzorce opad w i dystrybucję wody na calym świecie. Zmniejszone doladowanie może pogorszyc jakośc wody. Rosnące temperatury powierzchni i ekstremalne zdarzenia mogą wplywac na zakres i czas splywu oraz zwiększac parowanie. Dlatego ważne jest opracowanie racjonalnych strategii adaptacyjnych w celu zmniejszenia negatywnego wplywu zmian klimatu na zasoby wodne i zapewnienia ich zr wnoważonego rozwoju. Niniejsze badanie ma na celu zrozumienie, w jaki spos b zmiany klimatu wplywają na hydrologię i zasoby wodne zlewni Jatayu Ganga w Kumaun Himalaya. Jatayu Ganga jest gl wnym, zasilanym deszczem, nielodowcowym doplywem rzeki Saryu, obecnie zmniejszającym się w alarmującym tempie. Gl wnym celem badania jest zbadanie wplywu zmian klimatycznych na charakterystykę hydrologiczną, ocena zasob w wodnych w jednostkach mikro i analiza ich wzajemnych powiązań.

Si prevede che l'idrologia e il sistema idrologico della maggior parte dei bacini idrografici cambieranno a causa dei cambiamenti climatici. Questo cambiamento del bilancio idrico render difficile per i gestori delle risorse idriche soddisfare le richieste di popolazioni in crescita, ecosistemi fragili, agricoltori, allevatori, produttori di energia e industrie. I cambiamenti climatici influenzano i modelli delle precipitazioni e la distribuzione dell'acqua in tutto il mondo. La riduzione della ricarica pu degradare la qualit dell'acqua. L'aumento delle temperature superficiali e gli eventi estremi possono influenzare l'entit e i tempi di deflusso e aumentare l'evaporazione. quindi importante sviluppare strategie di adattamento razionali per ridurre gli impatti negativi dei cambiamenti climatici sulle risorse idriche e garantirne lo sviluppo sostenibile. Il presente studio mira a capire come i cambiamenti climatici stiano influenzando l'idrologia e le risorse idriche del bacino idrografico del Jatayu Ganga, nell'Himalaya Kumaun. Il Jatayu Ganga un importante affluente pluviale e non glaciale del fiume Saryu, che ora sta diminuendo a un ritmo allarmante.

L'hydrologie et le syst me hydrologique de la plupart des bassins versants devraient changer en raison du changement climatique. En raison de cette modification du bilan hydrique, les gestionnaires des ressources en eau auront du mal r pondre la demande des populations croissantes, des cosyst mes fragiles, des agriculteurs, des leveurs, des producteurs d' nergie et des industries. Le changement climatique affecte le r gime des pr cipitations et la distribution de l'eau dans le monde entier. La r duction de la recharge peut d grader la qualit de l'eau. L'augmentation des temp ratures de surface et les v nements extr mes peuvent avoir un impact sur l' tendue et le moment du ruissellement et augmenter l' vaporation. Il est donc important de d velopper des strat gies d'adaptation rationnelles pour r duire les impacts n gatifs du changement climatique sur les ressources en eau et assurer leur d veloppement durable. La pr sente tude vise comprendre comment le changement climatique affecte l'hydrologie et les ressources en eau du bassin versant du Jatayu Ganga dans l'Himalaya de Kumaun. Le Jatayu Ganga est un important affluent non glaciaire de la rivi re Saryu, aliment par les pluies, qui d cline aujourd'hui un rythme alarmant.

The aim of this study to develope new and best combination of Ginger Aloevera medicinal Juice, and make easily availave in the market to ready to serve. The gel extracted and ginger juice were preserved with 700 ppm potassium metabisulphite. The gel and juice were filled in 200ml bottles and crown corking. And then bottle was pasteurized at 85○C for 20 minutes and cooled. Aloevera gel and ginger juice mixed with sugar syrup which made with sugar and citric acid. After addition of the preservative KMS 70 ppm and filled in 200 ml bottles, juice is pasteurized at 85○C for 20 minutes. Then cooled it up to room temperature juice bottles stored at 10○C for one month of time period.

Dilemmas of a Trishanku presents a thought-provoking account of a society and a nation marked by its contradictions and seamlessly combines everyday social and political experiences with academic insights. The Pauranic story of a pious king called Trishanku, who probably still hangs between the heaven and earth, is used as a metaphor to capture the different nuances of dilemmas which we all face in life as individuals and as citizens.Based on both historical data and what sociologists call 'participant observation', this account dwells on the predicaments and struggles of post-independence India. It begins with a depiction of life in a moffusil town and moves on to examine closely the issues of caste, religion, governance, corruption, education, science, culture, and lot more.

"Advancements in Flexible Pavement Design and Traffic Safety" um livro abrangente que analisa as mais recentes inova es e metodologias no dom nio da engenharia de pavimentos, com um foco principal nos pavimentos flex veis e na sua intersec o com a seguran a rodovi ria. O livro come a com uma an lise detalhada das abordagens modernas ao projeto de pavimentos flex veis, incorporando materiais e t cnicas de constru o de ltima gera o. O livro aborda os principais desafios da engenharia de pavimentos e prop e solu es inovadoras para garantir a durabilidade, longevidade e efic cia em termos de custos. Al m disso, os autores salientam a import ncia de considerar a seguran a do tr fego como parte integrante do projeto de pavimentos, destacando a natureza interligada destes dois aspectos cr ticos da infraestrutura de transportes. Ao longo dos cap tulos, o livro explora estudos de caso e aplica es reais que demonstram implementa es bem-sucedidas de avan os em pavimentos flex veis, fornecendo aos leitores percep es pr ticas e li es aprendidas em v rios projectos.

"Advancements in Flexible Pavement Design and Traffic Safety" est un ouvrage complet qui se penche sur les derni res innovations et m thodologies dans le domaine de l'ing nierie des chauss es, en mettant l'accent sur les chauss es souples et leur interaction avec la s curit routi re. Le livre commence par un examen d taill des approches modernes de la conception des chauss es souples, int grant les mat riaux et les techniques de construction les plus r cents. Il aborde les principaux d fis de l'ing nierie des chauss es et propose des solutions innovantes pour garantir la durabilit , la long vit et la rentabilit . En outre, les auteurs soulignent l'importance de consid rer la s curit routi re comme partie int grante de la conception des chauss es, mettant en vidence la nature interconnect e de ces deux aspects critiques de l'infrastructure des transports. Tout au long des chapitres, le livre explore des tudes de cas et des applications du monde r el qui illustrent des mises en oeuvre r ussies des avanc es en mati re de chauss es souples, offrant aux lecteurs des aper us pratiques et des le ons tir es de divers projets.

"Advancements in Flexible Pavement Design and Traffic Safety" un libro completo che approfondisce le ultime innovazioni e metodologie nel campo dell'ingegneria delle pavimentazioni, con particolare attenzione alle pavimentazioni flessibili e alla loro intersezione con la sicurezza del traffico. Il libro si apre con un esame dettagliato dei moderni approcci alla progettazione delle pavimentazioni flessibili, che incorporano materiali e tecniche di costruzione all'avanguardia. Affronta le principali sfide dell'ingegneria delle pavimentazioni e propone soluzioni innovative per garantire durabilit , longevit ed economicit . Inoltre, gli autori sottolineano l'importanza di considerare la sicurezza del traffico come parte integrante della progettazione delle pavimentazioni, evidenziando la natura interconnessa di questi due aspetti critici delle infrastrutture di trasporto. Nel corso dei capitoli, il libro esplora casi di studio e applicazioni reali che illustrano le implementazioni di successo delle pavimentazioni flessibili, fornendo ai lettori spunti pratici e lezioni apprese da vari progetti.